Article

Tsc1-mTOR signaling controls the structure and function of midbrain dopamine neurons

2018-07-25

Abstract excerpt

<h4>Summary</h4> mTOR complex 1 (mTORC1) is a central coordinator of cell growth and metabolism. Mutations in regulators of mTORC1 cause syndromic disorders with a high prevalence of cognitive and psychiatric conditions. To elucidate the cellular origins of these manifestations, we conditionally deleted the gene encoding the mTORC1 negative regulator Tsc1 from mouse midbrain dopamine neurons, which modulate motor...

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Literature Corpus work: ce2989e8-1ffa-5f57-b36e-201842931775
DOI: 10.1101/376814

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