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Article

Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca2+ Influx via L-Type Ca2+ Channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Sept 2021

Hisatsune Chihiro, Shimada Tadayuki, Miyamoto Akitoshi, Lee Amy, Yamagata Kanato

Abstract excerpt

Tuberous sclerosis complex (TSC) is a multisystem developmental disorder characterized by hamartomas in various organs, such as the brain, lungs, and kidneys. Epilepsy, along with autism and intellectual disability, is one of the neurologic impairments associated with TSC that has an intimate relationship with developmental outcomes and quality of life. Sustained activation of the mammalian target of rapamycin...

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Identifiers

PMID: 34417327
DOI: 10.1523/JNEUROSCI.1930-20.2021
PMCID: PMC8482857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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