Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae.

International journal of molecular sciences - 27 Aug 2020

Gupta Rishikesh Kumar, Wasilewska Iga, Palchevska Oksana, Kuźnicki Jacek

Abstract excerpt

Stromal interaction molecule (STIM) proteins play a crucial role in store-operated calcium entry (SOCE) as endoplasmic reticulum Ca2+ sensors. In neurons, STIM2 was shown to have distinct functions from STIM1. However, its role in brain activity and behavior was not fully elucidated. The present study analyzed behavior in zebrafish (Danio rerio) that lacked stim2a. The mutant animals had no morphological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Signaling
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Hyperkinesis

Share to Pentylenetetrazole

Share to Sequence Analysis, RNA

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32867296
DOI: 10.3390/ijms21176198
PMCID: PMC7503814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae.PMID 32867296Read ↗

stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae.Semantic proximity Read ↗

Loss of Stim2 in zebrafish induces glaucoma-like phenotype.Semantic proximity Read ↗

The Ca2+ Sensor STIM in Human Diseases.Semantic proximity Read ↗

Orais and STIMs: physiological mechanisms and disease.Semantic proximity Read ↗

STIM1, an essential and conserved component of store-operated Ca2 <b>+</b> channel functionSemantic proximity Read ↗

L-type voltage-gated calcium channel agonists improve hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher Syndrome Type 1Semantic proximity Read ↗

Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.Semantic proximity Read ↗

C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli.Semantic proximity Read ↗

mTORC1 hyperactivation causes sensory integration deficits due to habenula impairmentSemantic proximity Read ↗

Stac1 Regulates Sensory Stimulus Induced Escape LocomotionSemantic proximity Read ↗

A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making.Semantic proximity Read ↗

L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.