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Article

Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.

European journal of endocrinology - 1 Oct 2015

Theodoropoulou Marily, Reincke Martin, Fassnacht Martin, Komada Masayuki

Abstract excerpt

Cushing's disease (CD) arises from pituitary-dependent glucocorticoid excess due to an ACTH-secreting corticotroph tumor. Genetic hits in oncogenes and tumor suppressor genes that afflict other pituitary tumor subtypes are not found in corticotrophinomas. Recently, a somatic mutational hotspot was found in up to half of corticotrophinomas in the USP8 gene that encodes a protein that impairs the downregulation of...

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Source

Identifiers

PMID: 26012588
DOI: 10.1530/EJE-15-0320

Genes

USP8
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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