Article

Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators

2022-09-09

Abstract excerpt

<h4>ABSTRACT</h4> Cushing’s disease (CD) is a serious endocrine disorder attributed to an ACTH-secreting pituitary neuroendocrine tumor (PitNET) that subsequently causes chronic hypercortisolemia. PitNET regression has been reported following treatment with the investigational selective glucocorticoid receptor (GR) modulator relacorilant, but the mechanisms behind that effect remain unknown. Human PitNET organoid...

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Literature Corpus work: 6c2791ab-6c27-5e54-bda0-4543dec13ab3
DOI: 10.1101/2022.09.07.506977

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