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Article

Cushing's disease: towards precision medicine.

Cell research - 1 Jun 2015

Kaiser Ursula B

Abstract excerpt

The pathogenesis of Cushing's disease is poorly understood; two recent reports identifying somatic mutations in USP8 in pituitary corticotroph tumors provide exciting advances in this field. These mutations alter EGFR trafficking and signaling, raising the prospect that EGFR inhibitors may move t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25930709
DOI: 10.1038/cr.2015.53
PMCID: PMC4456621

Genes

EGFR
USP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25930709-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Cushing's disease: towards precision medicine.PMID 25930709Read ↗

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Mutations in the deubiquitinase gene USP8 cause Cushing's disease.Semantic proximity Read ↗

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Clinical Spectrum of USP8 Pathogenic Variants in Cushing's DiseaseSemantic proximity Read ↗

The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the SpotlightSemantic proximity Read ↗

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