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Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin

2021-05-04

Abstract excerpt

The process wherein dividing cells exhaust proliferative capacity and enter into replicative senescence has become a prominent model for cellular aging in vitro . Despite decades of study, this cellular state is not fully understood in culture and even much less so during aging. Here, we revisit Leonard Hayflick’s original observation of replicative senescence in WI-38 human lung fibroblasts equipped with a batte...

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Literature Corpus work
df1ad9dd-313f-50e5-8699-6bce3d88ed5d
DOI
10.1101/2021.05.03.442497
Open publication

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Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and ChromatinDOI 10.1101/2021.05.03.442497
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