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An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

27 Feb 2019

Abstract excerpt

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. Here, we use single cell transcriptomics and mass spectrometry-based proteomics to quantify changes in cellular activity states across 30 cell types and chart the lung proteome of young and old mice. We show that aging leads to increased transcriptional noise, indicating...

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PMID: 30814501
DOI: 10.1038/s41467-019-08831-9

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