Article

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

2018-06-20

Abstract excerpt

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. We used single cell transcriptomics and mass spectrometry to quantify changes in cellular activity states of 30 cell types and the tissue proteome from lungs of young and old mice. Aging led to increased transcriptional noise, indicating deregulated epigenetic control. We observed...

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Literature Corpus work: 76af12af-4989-5f90-bc75-f35532b4efd1
DOI: 10.1101/351353

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