Article

Glomerular-Targeted Delivery of Low-Dose Prednisolone Attenuates Established Lupus Nephritis in MRL/lpr Mice

2026-08-06

Abstract excerpt

<h4>Background</h4> Lupus nephritis remains a major cause of chronic kidney disease and kidney failure in systemic lupus erythematosus. Glucocorticoids are central to treatment but are limited by systemic toxicity. We evaluated whether a previously characterized collagen IV α3-targeted liposomal nanoparticle formulation carrying low-dose prednisolone could attenuate established lupus nephritis in MRL/lpr mice. <h...

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Literature Corpus work: d77c14e6-2d6c-5851-8c5a-b70d9cc797f3
DOI: 10.64898/2026.08.01.742194

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