Article

Neutrophil Extracellular Trap Formation and Complement Activation Pathways Dominate Microbiota-dependent disease bias in lupus-prone female NZM2328 mice

2026-07-01

Abstract excerpt

Women are predisposed to systemic lupus erythematosus (SLE) with a prevalence ratio of up to 9:1 over men. Multiple mouse strains including NZM2328 exhibit strong female dominance in developing spontaneous lupus as in humans with SLE. While lupus-prone mice can develop disease under germ free (GF) condition, the role of gut microbiota in female bias for lupus nephritis is not investigated systematically. Here, usi...

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Literature Corpus work: 504e60ae-b425-59b9-b239-a35fdf3aa6ab
DOI: 10.64898/2026.06.28.735075

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