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Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

28 Apr 2025

Abstract excerpt

Abstract Prenatal exposure to glucocorticoids is linked to long‐term health risks in offspring, but the role of maternal gut microbiota in mediating these effects remains unclear. Here, we demonstrate that prenatal prednisone therapy (PPT) in humans and prenatal prednisone exposure (PPE) in rats result in sex‐specific long bone dysplasia in offspring, including reduced peak bone mass (PBM) and heightened...

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PMID: 40860437
DOI: 10.1002/imt2.70037

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