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A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling

1 Apr 2022

Abstract excerpt

Cellular heterogeneity of aortic valves complicates the mechanistic evaluation of the calcification processes in calcific aortic valve disease (CAVD), and animal disease models are lacking. In this study, we identify a disease-driver population (DDP) within valvular interstitial cells (VICs). Through stepwise single-cell analysis, phenotype-guided omic profiling, and network-based analysis, we characterize the...

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PMID: 35417712
DOI: 10.1016/j.celrep.2022.110685

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