Article

Human cerebral organoids model tumor infiltration and migration supported by astrocytes in an autologous setting

2025-01-29

Abstract excerpt

<h4>Summary</h4> Efforts to achieve precise and efficient tumor targeting of highly malignant brain tumors are constrained by the dearth of appropriate models to study the effects and potential side effects of radiation, chemotherapy, and immunotherapy on the most complex human organ, the brain. We established a cerebral organoid model of brain tumorigenesis in an autologous setting by overexpressing c-MYC as one...

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Literature Corpus work: deefb419-1f38-5397-b300-c66b8298c793
DOI: 10.1101/2025.01.29.635456

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