Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically engineered cerebral organoids model brain tumor formation.

Nature methods - 1 Aug 2018

Bian Shan, Repic Marko, Guo Zhenming, Kavirayani Anoop, Burkard Thomas, Bagley Joshua A, Krauditsch Christian, Knoblich Jürgen A

Abstract excerpt

Brain tumors are among the most lethal and devastating cancers. Their study is limited by genetic heterogeneity and the incompleteness of available laboratory models. Three-dimensional organoid culture models offer innovative possibilities for the modeling of human disease. Here we establish a 3D in vitro model called a neoplastic cerebral organoid (neoCOR), in which we recapitulate brain tumorigenesis by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, myc
Share to Genetic Engineering
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterografts

Share to Human Embryonic Stem Cells

Share to Oncogenes

Share to Organoids

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 30038414
DOI: 10.1038/s41592-018-0070-7
PMCID: PMC6071863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically engineered cerebral organoids model brain tumor formation.PMID 30038414Read ↗

Modeling Patient-Derived Glioblastoma with Cerebral OrganoidsSemantic proximity Read ↗

Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma ProgressionSemantic proximity Read ↗

Modeling glioblastoma tumor progression via CRISPR-engineered brain organoidsSemantic proximity Read ↗

TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitroSemantic proximity Read ↗

Pioneering models of pediatric brain tumors.Semantic proximity Read ↗

Stem cell modeling of nervous system tumors.Semantic proximity Read ↗

Modeling nervous system tumors with human stem cells and organoidsSemantic proximity Read ↗

Advancing Glioblastoma Research with Innovative Brain Organoid-Based ModelsSemantic proximity Read ↗

Developmental origins of brain tumors.Semantic proximity Read ↗

Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future.Semantic proximity Read ↗

Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoidsSemantic proximity Read ↗

In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.