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Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids

15 Feb 2021

Abstract excerpt

Emerging three-dimensional (3D) cultures of glioblastoma are becoming powerful models to study glioblastoma stem cell behavior and the impact of cell-cell and cell-microenvironment interactions on tumor growth and invasion. Here we describe a method for culturing human glioblastoma stem cells (GSCs) in 3D by co-culturing them with pluripotent stem cell-derived brain organoids. This requires multiple coordinated...

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PMID: 33619017
DOI: 10.1242/bio.056416

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