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In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

6 Jul 2022

Abstract excerpt

Genome-wide CRISPR screens have been extremely useful in identifying therapeutic targets in diverse cancers by defining genes that are essential for malignant growth. However, most CRISPR screens were performed in vitro and thus cannot identify genes that are essential for interactions with the microenvironment in vivo. Here, we report genome-wide CRISPR screens in 2 in vivo murine models of acute myeloid...

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PMID: 35793392
DOI: 10.1182/bloodadvances.2022007250

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