Article

<i>In vivo</i> genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

2020-12-22

Abstract excerpt

An enhanced requirement for extracellular nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy for evaluating dependencies in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 as a unique vulnerability in this disease. In accord with this transport function, we demonstrate that the SLC5A3 dependency reflects a...

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Identifiers and source

Literature Corpus work: c02550df-f35f-5fc3-973e-d53306b34049
DOI: 10.1101/2020.12.22.424018

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