Matrix abnormalities in pulmonary fibrosis.

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by excessive scarring, which leads to increased tissue stiffness, loss in lung function and ultimately death. IPF is characterised by progressive fibroblast and myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Myofibroblasts play a key role in ECM deposition. Transforming growth factor (TGF)-β1 is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cellular Microenvironment
• Share to Extracellular Matrix