Decoding mechanosensitive genes in cardiac fibroblasts via 3D hydrogel models of fibrosis

Abstract excerpt

Cardiac fibrosis arises from the abnormal activation of cardiac fibroblasts (CFs) in response to both chemical and mechanical stressors. While extracellular matrix (ECM) stiffness is a key determinant of fibroblast behavior, the molecular mechanisms linking mechanical signals to gene expression remain poorly understood. To address this gap, we developed a three-dimensional (3D) hydrogel system that mimics the ECM...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Fibrosis and Remodeling
• Share to Cellular Mechanics and Interactions
• Share to Tissue Engineering and Regenerative Medicine