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Article

Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function.

Biomaterials science - 27 Sept 2022

Bomb Kartik, Pradhan Lina, Zhang Qi, Jarai Bader M, Bhattacharjee Arnab, Burris David L, Kloxin April M, Fromen Catherine A

Abstract excerpt

The pulmonary fibrotic microenvironment is characterized by increased stiffness of lung tissue and enhanced secretion of profibrotic soluble cues contributing to a feedback loop that leads to dysregulated wound healing and lung failure. Pinpointing the individual and tandem effects of profibrotic stimuli in impairing immune cell response remains difficult and is needed for improved therapeutic strategies. We...

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Source

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Identifiers

PMID: 36018297
DOI: 10.1039/d2bm00828a
PMCID: PMC9632634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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