Article

Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimic

2023-02-24

Abstract excerpt

The lung extracellular matrix (ECM) maintains the structural integrity of the tissue and regulates the phenotype and functions of resident fibroblasts. Lung-metastatic breast cancer alters these cell-ECM interactions, promoting fibroblast activation. There is a need for bio-instructive ECM models that contain the ECM composition and biomechanics of the lung to study these cell-matrix interactions in vitro . Here,...

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Literature Corpus work: 7395d7d1-a2cf-59d4-ab28-bcf0f222d7a7
DOI: 10.1101/2023.02.24.529926

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