Article

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosis

2025-02-17

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable lung disease characterized by tissue scarring that disrupts gas exchange. Epithelial cell dysfunction, fibroblast activation, and excessive extracellular matrix deposition drive this pathology that ultimately leads to respiratory failure. Mechanistic studies have shown that repeated injury to alveolar epithelial cells initiates an aberrant wound-he...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e6487e0-1ed1-5f0f-9eef-21e45a268634
DOI: 10.1101/2025.02.12.637970

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosisDOI 10.1101/2025.02.12.637970Read

Dynamic hybrid-hydrogel lung models decouple matrix composition, stiffness, and fibroblast memory to define distinct drivers of fibrotic progressionSemantic proximity Read

Pulmonary Matrix Derived Hydrogels from Patients with Idiopathic Pulmonary Fibrosis Induce a Proinflammatory State in Lung Fibroblasts <i>In Vitro</i>Semantic proximity Read

Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung modelsSemantic proximity Read

Fibrotic human lung extracellular matrix as a disease-specific substrate for 3D <i>in-vitro</i> models of pulmonary fibrosisSemantic proximity Read

Engineering a 3D Lung Co-culture Platform to Model Epithelial–Fibroblast Interactions in Pulmonary FibrosisSemantic proximity Read

In Vitro Modeling of Idiopathic Pulmonary Fibrosis: Lung-on-a-Chip Systems and Other 3D CulturesSemantic proximity Read

Hydrogel-Embedded Precision-Cut Lung Slices Recapitulate Fibrotic Gene Expression and Enable Therapeutic Response EvaluationSemantic proximity Read

Development of a Novel Air-Liquid Interface Airway Tissue Equivalent Model for In Vitro Respiratory Modeling StudiesSemantic proximity Read

Development of a novel air-liquid interface airway tissue equivalent model for in vitro respiratory modeling studies.Semantic proximity Read

Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosisSemantic proximity Read

Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary FibrosisSemantic proximity Read

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.Semantic proximity Read