Article

Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

2022-10-27

Abstract excerpt

Parkinson’s disease-causing LRRK2 mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead to higher levels of cellular Rab phosphorylation than kinase-activating mutations. Here, we investigated whether mutation-dependent differences in LRRK2 cellular localization could explain this discrepancy. We disc...

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Literature Corpus work: 786a3093-46e3-55ac-9d91-54d5f852816e
DOI: 10.1101/2022.10.25.513743

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