Article

Integrative benchmarking and automation of clonal reconstruction of somatic mutations in single-sample tumor genome analysis

2026-08-05

Abstract excerpt

Abstract Background Accurate identification of truncal mutations, those present in all tumor cells, is essential for understanding tumor evolution and guiding downstream analyses in cancer genomics, including detection of minimal residual disease. Existing clonal reconstruction tools vary in accuracy, specificity, and computational efficiency, and, to our knowledge, no standardized workflow exists for systematic t...

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Literature Corpus work: debee280-eda3-5daf-9268-7ba717cfd7aa
DOI: 10.1186/s12859-026-06589-8

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