Article

MAESTRO affords ‘breadth and depth’ for mutation testing

2021-01-24

Abstract excerpt

The ability to assay large numbers of low-abundance mutations is crucial in biomedicine. Yet, the technical hurdles of sequencing multiple mutations at extremely high depth and accuracy remain daunting. For sequencing low-level mutations, it’s either ‘depth or breadth’ but not both. Here, we report a simple and powerful approach to accurately track thousands of distinct mutations with minimal reads. Our technique...

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Literature Corpus work: 9efb6fd1-a1f0-532d-879b-f64ce24e53b5
DOI: 10.1101/2021.01.22.427323

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