Article

Investigating the role of APOE: limitations of human pluripotent stem cell-derived cerebral organoids

2020-12-01

Abstract excerpt

<h4>Summary</h4> Apolipoprotein E (APOE) is the most important susceptibility gene for late onset of Alzheimer’s disease, with the presence of APOE-ε4 associated with increased risk of developing Alzheimer’s disease. Here, we reprogrammed human fibroblasts from individuals with different APOE-ε genotypes into induced pluripotent stem cells, and generated isogenic lines with different APOE profiles. We then diffe...

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Literature Corpus work: 818a7f6c-6b3e-5da1-a658-4c4bac686437
DOI: 10.1101/2020.11.30.405654

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