Article

A DNA methylome biosignature in alveolar macrophages from TB-exposed individuals predicts exposure to mycobacteria

2021-03-20

Abstract excerpt

Several studies have identified biomarkers for tuberculosis (TB) diagnosis based on blood cell transcriptomics. Here, we instead studied epigenomics in the lung compartment by obtaining induced sputum from subjects included in a TB contact tracing. CD3- and HLA-DR-positive cells were isolated from the collected sputum and DNA methylome analyses performed. Unsupervised cluster analysis revealed that DNA methylomes...

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Literature Corpus work: de7f5339-1ed6-57d5-a46e-dba3323dea57
DOI: 10.1101/2021.03.16.21253732

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