Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individuals

28 Nov 2020

Abstract excerpt

We hypothesised that individuals with immunological sensitisation to Mycobacterium tuberculosis (Mtb), conventionally regarded as evidence of latent tuberculosis infection (LTBI), would demonstrate binary responses to preventive therapy (PT), reflecting the differential immunological consequences of the sterilisation of viable infection in those with active Mtb infection versus no Mtb killing in those who did not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mycobacterium research and diagnosis
Share to RNA and protein synthesis mechanisms
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33524936
DOI: 10.1016/j.tube.2020.102033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individualsPMID 33524936Read ↗

Detectable Changes in The Blood Transcriptome Are Present after Two Weeks of Antituberculosis TherapySemantic proximity Read ↗

Immune profiling in M. tuberculosis infection enables stratification of patients with active diseaseSemantic proximity Read ↗

Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent TuberculosisSemantic proximity Read ↗

A blood RNA transcript signature for TB exposure in household contactsSemantic proximity Read ↗

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infectionSemantic proximity Read ↗

Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active TuberculosisSemantic proximity Read ↗

Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysisSemantic proximity Read ↗

Single-cell immune profiling at time of <i>M. tuberculosis</i> exposure reveals antigen-reactive programs that predict progression to active diseaseSemantic proximity Read ↗

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection.Semantic proximity Read ↗

Identification of host gene expression biomarkers for tuberculosisSemantic proximity Read ↗

Suppression of host gene expression is associated with latent TB infection: a possible diagnostic biomarkerSemantic proximity Read ↗

Airway immune signatures of protection and disease progression in recent human tuberculosis household contactsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.