Article

DNA methylation profiling of immune cells from tuberculosis-exposed individuals overlaps with BCG-induced epigenetic changes and correlates with the emergence of anti-mycobacterial ‘corralling cells’

2021-09-03

Abstract excerpt

The mechanism of protection of the only approved tuberculosis (TB) vaccine, Bacillus Calmette Guérin (BCG) is poorly understood. In recent years, epigenetic modifications induced by BCG have been demonstrated to reflect a state of trained immunity. The concept of trained immunity is now explored as a potential prevention strategy for a variety of infections. Studies on human TB immunity are dominated by those usin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3aac4d0-ca9e-5355-9e0b-d39e3b8c85ae
DOI: 10.1101/2021.09.01.21262945

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA methylation profiling of immune cells from tuberculosis-exposed individuals overlaps with BCG-induced epigenetic changes and correlates with the emergence of anti-mycobacterial ‘corralling cells’DOI 10.1101/2021.09.01.21262945Read

DNA Methylation Profiles of Immune Cells From Tuberculosis-Exposed Individuals Overlap With BCG-Induced Epigenetic ChangesSemantic proximity Read

A DNA methylome biosignature in alveolar macrophages from TB-exposed individuals predicts exposure to mycobacteriaSemantic proximity Read

The spectrum of tuberculosis described as differential DNA methylation patterns in alveolar macrophages and alveolar T cellsSemantic proximity Read

DNA methylomes derived from alveolar macrophages and alveolar T cells display distinct patterns in tuberculosis – a future precision tool for TB status determination?Semantic proximity Read

Surveying the Epigenetic Landscape of Tuberculosis in Alveolar MacrophagesSemantic proximity Read

Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytesSemantic proximity Read

Current Understanding of Bacillus Calmette-Guérin-Mediated Trained Immunity and Its Perspectives for Controlling Intracellular InfectionsSemantic proximity Read

Lineage 2–Beijing <i>Mycobacterium tuberculosis</i> strains suppress BCG-trained innate immunity early after infectionSemantic proximity Read

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis BiomarkersSemantic proximity Read

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.Semantic proximity Read

Epigenetic orchestration of host immune defences by Mycobacterium tuberculosisSemantic proximity Read

Epigenetic code during mycobacterial infections: therapeutic implications for tuberculosisSemantic proximity Read