Back to search

Article

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

2019-10-16

Abstract excerpt

Mycobacterium tuberculosis (Mtb ) has co-evolved with humans for millennia and developed multiple mechanisms to evade host immunity. Restoring host immunity in order to shorten existing therapy and improve outcomes will require identifying the full complement by which host immunity is inhibited. Perturbing host DNA methylation is a mechanism induced by chronic infections such as HIV, HPV, LCMV and schistosomiasis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1f67aa66-ca3b-57d0-8502-89ab3f73bcc3
DOI
10.1101/805457
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial ImmunityDOI 10.1101/805457
DNA hypermethylation during tuberculosis dampens host immune responsivenessSemantic proximity
Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune ChangesSemantic proximity
The Role of Epigenetics in Tuberculosis InfectionSemantic proximity
Epigenetic code during mycobacterial infections: therapeutic implications for tuberculosisSemantic proximity
Epigenetic Mechanisms Induced by Mycobacterium tuberculosis to Promote Its Survival in the HostSemantic proximity
Epigenetic Modulation of Host Immunity related genes in Pulmonary Tuberculosis: A Comprehensive Analysis of DNA Methylation Profiles in Peripheral Blood Mononuclear CellsSemantic proximity
Distinct epigenetic regulation in patients with multidrug-resistant TB-HIV co-infection and uninfected individuals.Semantic proximity
Immunomodulation by epigenome alterations in Mycobacterium tuberculosis infectionSemantic proximity
Epigenetic changes in Mycobacterium tuberculosis and its host provide potential targets or biomarkers for drug discovery and clinical diagnosisSemantic proximity
Methylome-wide analysis reveals epigenetic marks associated with resistance to tuberculosis in HIV-infected individuals from East AfricaSemantic proximity
The Epigenetic Modifications of Genes Associated with Tuberculosis Susceptibility and Implications for Epi-Drugs.Semantic proximity
Epigenetic orchestration of host immune defences by Mycobacterium tuberculosisSemantic proximity
Select a neighboring publication to make it the new centre.