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DNA Methylation Profiles of Immune Cells From Tuberculosis-Exposed Individuals Overlap With BCG-Induced Epigenetic Changes

2022-01-05

Abstract excerpt

The mechanism of protection of the only approved tuberculosis (TB) vaccine, Bacillus Calmette Guérin (BCG) is poorly understood. In recent years, epigenetic modifications induced by BCG have been demonstrated to reflect a state of trained immunity. The concept of trained immunity is now explored as a potential prevention strategy for a variety of infections. Studies on human TB immunity are dominated by those usin...

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Literature Corpus work
cba88e00-b2c0-5ccf-ac4b-b05eb6759286
DOI
10.21203/rs.3.rs-1157082/v1
Open publication

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DNA Methylation Profiles of Immune Cells From Tuberculosis-Exposed Individuals Overlap With BCG-Induced Epigenetic ChangesDOI 10.21203/rs.3.rs-1157082/v1
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