Article

Targeting AKAP13 RhoGEF activity ameliorates pro-fibrotic phenotypes driven by the IPF associated <i>AKAP13</i> risk variant

2026-01-23

Abstract excerpt

<h4>Rationale</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive, incurable scarring disease of the lung. A common genetic variant near AKAP13, a multifunctional scaffold protein that integrates intracellular signalling through its interactions with RhoA and protein kinase A (PKA), has been associated with IPF susceptibility and elevated AKAP13 mRNA expression in lung tissue from patients. However, its co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb35f8f7-9aa7-5e85-92f2-b98dd85cbe1e
DOI: 10.64898/2026.01.21.700846

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting AKAP13 RhoGEF activity ameliorates pro-fibrotic phenotypes driven by the IPF associated <i>AKAP13</i> risk variantDOI 10.64898/2026.01.21.700846Read

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.Semantic proximity Read

Retrospective transcriptome analyses identify <i>LINC01013</i> as an activation marker in human dermal fibroblastsSemantic proximity Read

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosisSemantic proximity Read

Transcriptomic and Epigenetic Profiling of Fibroblasts in Idiopathic Pulmonary Fibrosis.Semantic proximity Read

Burden of rare pathogenic variants suggests disrupted cytoskeletal organisation in the pathogenesis of pulmonary fibrosisSemantic proximity Read

Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFβ-mediated α-SMA cytoskeleton assembly and autophagy.Semantic proximity Read

Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPFSemantic proximity Read

lncITPF Promotes Pulmonary Fibrosis by Targeting hnRNP-L Depending on Its Host Gene ITGBL1Semantic proximity Read

An Integrative Genotyping and Gene Expression Profiling of the Mutated Human FAM111B Gene and Fibrosis-Associated Pathway in the POIKTMP Syndrome.Semantic proximity Read

FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition.Semantic proximity Read

Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transitionSemantic proximity Read

Therapeutic p63 isoform switching rescues epidermal defects in AEC syndrome.Semantic proximity Read