Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2016

Wolter J, Schild L, Bock F, Hellwig A, Gadi I, Al-Dabet M M, Ranjan S, Rönicke R, Nawroth P P, Petersen K-U, Mawrin C, Shahzad K, Isermann B

Abstract excerpt

Essentials The role of protein C (PC) activation in experimental autoimmune encephalitis (EAE) is unknown. PC activation is required for mitochondrial function in the central nervous system. Impaired PC activation aggravates EAE, which can be compensated for by soluble thrombomodulin. Protection of myelin by activated PC or solulin is partially independent of immune-modulation. SUMMARY: Background Studies with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiolipins
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune System

Share to Myelin Sheath

Share to PC12 Cells

Share to Protein C

Share to Solubility

Share to Thrombomodulin

Source

Identifiers

PMID: 27590316
DOI: 10.1111/jth.13494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system.PMID 27590316Read ↗

Soluble TREM2 induces microglia dysfunction and brain damage while cleavage-reduced TREM2 shows sustained microglia activation with enhanced myelination in the cuprizone modelSemantic proximity Read ↗

The protein C pathwaysSemantic proximity Read ↗

Soluble TREM2 induces microglia dysfunction and brain damage while cleavage-reduced TREM2 shows sustained microglia activation with enhanced remyelination in the cuprizone modelSemantic proximity Read ↗

Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signallingSemantic proximity Read ↗

Protein C anticoagulant and cytoprotective pathways.Semantic proximity Read ↗

Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis.Semantic proximity Read ↗

Activated protein C: biased for translationSemantic proximity Read ↗

A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis.Semantic proximity Read ↗

Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.Semantic proximity Read ↗

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.Semantic proximity Read ↗

C57BL6 mouse substrains demonstrate differences in susceptibility to the demyelinating effects of Cuprizone toxinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.