Article

Single-cell variations of circadian clock and immune gene expression in microglia and neurodegeneration

2024-06-16

Abstract excerpt

<h4>Summary</h4> We investigated the diurnal rhythmicity of gene expression in microglia, the resident macrophages of the brain, in health and disease. Using RNA sequencing and single-cell analysis by RNAscope, we examined wild-type mice and the R6/2 transgenic mouse model of Huntington’s disease (HD). Our findings suggest context-dependent rhythmic gene expression in microglia, exhibiting substantial variability...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de1f329e-0cf0-5f01-8192-a23eb3b5586b
DOI: 10.1101/2024.06.16.599193

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell variations of circadian clock and immune gene expression in microglia and neurodegenerationDOI 10.1101/2024.06.16.599193Read

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.Semantic proximity Read

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brainSemantic proximity Read

Microglia undergo transcriptional, translational and functional adaptations to dark and light phases in laboratory miceSemantic proximity Read

Age-associated microglia populations identified from several single cell transcriptome dataSemantic proximity Read

The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophagesSemantic proximity Read

A glial circadian gene expression atlas reveals cell type and disease-specific reprogramming in response to amyloid pathology or agingSemantic proximity Read

Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging ClocksSemantic proximity Read

NOX2 Inhibition Enables Retention of the Circadian Clock in BV2 Microglia and Primary MacrophagesSemantic proximity Read

Single-cell multiomics reveals microglia–neuron granulin signaling associated with brain agingSemantic proximity Read

Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model MiceSemantic proximity Read

Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease.Semantic proximity Read

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencingSemantic proximity Read