Article
From the Cover: Genomic Effects of Androstenedione and Sex-Specific Liver Cancer Susceptibility in Mice.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2017
Rooney John P, Ryan Natalia, Chorley Brian N, Hester Susan D, Kenyon Elaina M, Schmid Judith E, George Barbara Jane, Hughes Michael F, Sey Yusupha M, Tennant Alan, MacMillan Denise K, Simmons Jane Ellen, McQueen Charlene A, Pandiri Arun, Wood Charles E, Corton J Christopher
Abstract excerpt
Current strategies for predicting carcinogenic mode of action for nongenotoxic chemicals are based on identification of early key events in toxicity pathways. The goal of this study was to evaluate short-term key event indicators resulting from exposure to androstenedione (A4), an androgen receptor agonist and known liver carcinogen in mice. Liver cancer is more prevalent in men compared with women, but...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.