Article
Biased localization of actin binding proteins by actin filament conformation.
Nature communications - 25 Nov 2020
Harris Andrew R, Jreij Pamela, Belardi Brian, Joffe Aaron M, Bausch Andreas R, Fletcher Daniel A
Abstract excerpt
The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins localize differentially to these structures within a shared cytoplasm remains unclear. Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conformational changes. Using a combination of live cell imaging and in vitro single molecule binding...
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