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Article

Large-scale opening of utrophin's tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011

Lin Ava Y, Prochniewicz Ewa, James Zachary M, Svensson Bengt, Thomas David D

Abstract excerpt

We have used site-directed spin labeling and pulsed electron paramagnetic resonance to resolve a controversy concerning the structure of the utrophin-actin complex, with implications for the pathophysiology of muscular dystrophy. Utrophin is a homolog of dystrophin, the defective protein in Duchenne and Becker muscular dystrophies, and therapeutic utrophin derivatives are currently being developed. Both proteins...

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Identifiers

PMID: 21768337
DOI: 10.1073/pnas.1106453108
PMCID: PMC3150896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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