Article

Cockayne syndrome patient iPSC-derived brain organoids and neurospheres show early transcriptional dysregulation of biological processes associated with brain development and metabolism

2023-10-17

Abstract excerpt

<h4>Summary</h4> Cockayne syndrome is a rare hereditary autosomal recessive disorder characterized by diverse neurological afflictions. However, little is known about the cerebral development in CS patients. We generated neurospheres and cerebral organoids utilizing Cockayne Syndrome B Protein (CSB) deficient induced pluripotent stem cells derived from two patients with distinct severity levels of CS and healthy...

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Literature Corpus work: de026aed-0411-51f5-863d-5806e662dfc7
DOI: 10.1101/2023.10.17.562706

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