Article

Identification and functional characterization of an AMD associated c-ABL binding SNP streak within the ARMS2 gene promoter region

2025-10-27

Abstract excerpt

<h4>Background</h4> Large-scale genome-wide association studies (GWAS) have identified the human 10q26 locus as a major genetic risk factor for age-related macular degeneration (AMD). The AMD-associated interval has been refined to a 5,196 bp segment flanking the ARMS2–HTRA1 region, excluding HTRA1 and the ARMS2 3′ indel (443del54ins) variant by risk haplotype analysis. Although the missense SNP rs10490924 has b...

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Literature Corpus work: de00013a-bdd5-5b4e-9cf1-c3a7dc383ce2
DOI: 10.1101/2025.10.27.684937

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