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Article

Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro.

The Journal of biological chemistry - 1 Jan 2000

Pan Yang, Iejima Daisuke, Nakayama Mao, Suga Akiko, Noda Toru, Kaur Inderjeet, Das Taraprasad, Chakrabarti Subhabrata, Guymer Robyn H, DeAngelis Margaret M, Yamamoto Megumi, Baird Paul N, Iwata Takeshi

Abstract excerpt

The disease-initiating molecular events for age-related macular degeneration (AMD), a multifactorial retinal disease affecting many millions of elderly individuals worldwide, are still unknown. Of the over 30 risk and protective loci so far associated with AMD through whole genome-wide association studies (GWAS), the Age-Related Maculopathy Susceptibility 2 (ARMS2) gene locus represents one of the most highly...

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Identifiers

PMID: 33636181
DOI: 10.1016/j.jbc.2021.100456
PMCID: PMC8039566

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Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro.PMID 33636181Read ↗

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HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration.Semantic proximity Read ↗

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