Synergistic Notch–WNT Activation Underlies Pediatric Dilated Cardiomyopathy

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Therapies for pediatric idiopathic dilated cardiomyopathy (iDCM) are extrapolated from adult heart failure despite limited efficacy, suggesting fundamental biological differences. Our prior transcriptomic studies indicate activation of developmental signaling pathways, including Notch and WNT, in pediatric iDCM; however, their mechanistic contribution remains unknown. We tes...

Topics

Open a Topic to create a Post that cites this publication.

• Cardiac Fibrosis and Remodeling
• Cardiomyopathy and Myosin Studies
• Congenital Diaphragmatic Hernia Studies
• Congenital heart defects research
• Congenital Heart Disease Studies
• Genetics and Neurodevelopmental Disorders
• RNA Research and Splicing
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

dde6f979-34b2-55ff-9b4a-47e2750fcae3

DOI

10.1101/2025.06.07.658396