Article

Age-dependent Transcriptional Programs Distinguish Pediatric from Adult Dilated Cardiomyopathy

2026-03-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Current management of pediatric dilated cardiomyopathy (DCM) in children relies on guideline-directed medical therapy (GDMT) extrapolated from adult heart failure. However, due to small sample size, randomized trials of GDMT agents in children have failed to demonstrate efficacy and mortality benefits seen in adults, suggesting fundamental differences in disease mechanisms....

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Literature Corpus work: 4a9590cc-528f-568f-8f94-31ba76b1c66f
DOI: 10.64898/2026.03.17.26348665

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