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Article

Wnt11 regulates cardiac chamber development and disease during perinatal maturation

6 Sept 2017

Abstract excerpt

Ventricular chamber growth and development during perinatal circulatory transition is critical for functional adaptation of the heart. However, the chamber-specific programs of neonatal heart growth are poorly understood. We used integrated systems genomic and functional biology analyses of the perinatal chamber specific transcriptome and we identified Wnt11 as a prominent regulator of chamber-specific...

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PMID: 28878122
DOI: 10.1172/jci.insight.94904

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