Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric Myocardium

Abstract excerpt

<h4>Background</h4> Nearly 1% or 1.3 million babies are born with congenital heart disease (CHD) globally each year – many of whom will require palliative or corrective heart surgery within the first few years of life. A detailed understanding of cardiac maturation can help to expand our knowledge on cardiac diseases that develop during gestation, identify age-appropriate cardiovascular drug therapies, and inform...

Topics

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• Cardiac electrophysiology and arrhythmias
• Cardiovascular Effects of Exercise
• Cardiovascular Function and Risk Factors
• Congenital heart defects research
• Congenital Heart Disease Studies
• Ion channel regulation and function
• Pluripotent Stem Cells Research
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

96c51335-c93d-58b2-8c6e-8e358f4bb786

DOI

10.1101/2024.04.19.589826