Article

Activated fibroblasts drive cellular interactions in end-stage pediatric hypertrophic cardiomyopathy

2024-01-29

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a relatively rare but debilitating diagnosis in the pediatric population and patients with end-stage HCM require heart transplantation. In this study, we performed single-nucleus RNA sequencing on pediatric HCM and control myocardium. We identified distinct underling cellular processes in pediatric, end-stage HCM in cardiomyocytes, fibroblasts, endothelial cells, and myeloid ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9834b6de-7cf2-59da-82fb-96a88d6c936a
DOI: 10.1101/2024.01.25.577226

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activated fibroblasts drive cellular interactions in end-stage pediatric hypertrophic cardiomyopathyDOI 10.1101/2024.01.25.577226Read

Single Nuclei Sequencing Reveals Novel Insights Into the Regulation of Cellular Signatures in Children With Dilated CardiomyopathySemantic proximity Read

Lineage-specific regulatory changes in the pathological cardiac remodeling of hypertrophy cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomicsSemantic proximity Read

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathiesSemantic proximity Read

Integrated multi-omic characterization of congenital heart disease.Semantic proximity Read

Role of TPM2 in Pediatric Restrictive Cardiomyopathy: Insights from Single-Nucleus RNA Sequencing and Proteomic AnalysisSemantic proximity Read

Single-cell transcriptomics provides insights into hypertrophic cardiomyopathySemantic proximity Read

Cellular and Transcriptional Landscape of Human Hypoplastic Left Heart SyndromeSemantic proximity Read

Pediatric dilated cardiomyopathy hearts display a unique gene expression profileSemantic proximity Read

Beyond cardiomyocytes: Cellular diversity in the heart's response to exerciseSemantic proximity Read

HeartMap: An Integrated Cell Atlas of 2.4 million cells across 209 Individuals in Health and DiseaseSemantic proximity Read

Integrated single-cell and spatial multiomic analysis reveals widespread reactivation of developmental programs in diseased human heartsSemantic proximity Read

Altered Intercellular Communication and Extracellular Matrix Signaling as a Potential Disease Mechanism in Human Hypertrophic CardiomyopathySemantic proximity Read