Genomic characterization of malignant progression in neoplastic pancreatic cysts.

doi:10.1038/s41467-020-17917-8

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Article

Genomic characterization of malignant progression in neoplastic pancreatic cysts.

Nature communications - 14 Aug 2020

Noë Michaël, Niknafs Noushin, Fischer Catherine G, Hackeng Wenzel M, Beleva Guthrie Violeta, Hosoda Waki, Debeljak Marija, Papp Eniko, Adleff Vilmos, White James R, Luchini Claudio, Pea Antonio, Scarpa Aldo, Butturini Giovanni, Zamboni Giuseppe, Castelli Paola, Hong Seung-Mo, Yachida Shinichi, Hiraoka Nobuyoshi, Gill Anthony J, Samra Jaswinder S, Offerhaus G Johan A, Hoorens Anne, Verheij Joanne, Jansen Casper, Adsay N Volkan, Jiang Wei, Winter Jordan, Albores-Saavedra Jorge, Terris Benoit, Thompson Elizabeth D, Roberts Nicholas J, Hruban Ralph H, Karchin Rachel, Scharpf Robert B, Brosens Lodewijk A A, Velculescu Victor E, Wood Laura D

Abstract excerpt

Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs) are non-invasive neoplasms that are often observed in association with invasive pancreatic cancers, but their origins and evolutionary relationships are poorly understood. In this study, we analyze 148 samples from IPMNs, MCNs, and small associated invasive carcinomas from 18 patients using whole exome or targeted sequencing....

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Identifiers

PMID: 32796935
DOI: 10.1038/s41467-020-17917-8
PMCID: PMC7428044

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