Article

The <i>DNAJB1–PRKACA</i> Oncogenic Fusion Drives Stepwise Biliary and Pancreatic Carcinogenesis from Intraductal Precursor Lesions

2026-05-27

Abstract excerpt

<h4>SUMMARY</h4> Intraductal oncocytic papillary neoplasms (IOPNs) are rare tumors that develop from biliary and pancreatic ductal epithelium and progress to lethal cancers. Human IOPNs and IOPN-associated carcinomas are known to harbor the DNAJB1-PRKACA gene fusion, however the role of the oncogenic fusion in carcinogenesis is poorly understood. We developed a Cre-inducible mouse model of human DNAJB1-PRKACA ex...

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Literature Corpus work: 98fc0c6e-89c5-5d2b-ae0c-dca8479a3796
DOI: 10.64898/2026.05.23.727425

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