Article
Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions.
Gut - 1 May 2021
Fujikura Kohei, Hosoda Waki, Felsenstein Matthäus, Song Qianqian, Reiter Johannes G, Zheng Lily, Beleva Guthrie Violeta, Rincon Natalia, Dal Molin Marco, Dudley Jonathan, Cohen Joshua D, Wang Pei, Fischer Catherine G, Braxton Alicia M, Noë Michaël, Jongepier Martine, Fernández-Del Castillo Carlos, Mino-Kenudson Mari, Schmidt C Max, Yip-Schneider Michele T, Lawlor Rita T, Salvia Roberto, Roberts Nicholas J, Thompson Elizabeth D, Karchin Rachel, Lennon Anne Marie, Jiao Yuchen, Wood Laura D
Abstract excerpt
OBJECTIVE: Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor lesions that can progress to invasive pancreatic cancer and are classified as low-grade or high-grade based on the morphology of the neoplastic epithelium. We aimed to compare genetic alterations in low-grade and high-grade regions of the same IPMN in order to identify molecular alterations underlying neoplastic progression....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.