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Article

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

15 Jun 1997

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9218810
DOI: 10.1093/emboj/16.12.3693

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6kPMID 9218810Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.Semantic proximity Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

Differential translation of TOP mRNAs in rapamycin-treated human B lymphocytes.Semantic proximity Read ↗

A critical role for non-coding RNA <i>GAS5</i> in growth arrest and rapamycin inhibition in human T-lymphocytesSemantic proximity Read ↗

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.Semantic proximity Read ↗

Reversal of G-Quadruplexes’ Role in Translation Control When Present in the Context of an IRESSemantic proximity Read ↗

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomesSemantic proximity Read ↗

Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translationSemantic proximity Read ↗

mTOR pathway inhibition stimulates pharmacologically induced nonsense suppressionSemantic proximity Read ↗

Regulation of Interferon-Dependent mRNA Translation of Target GenesSemantic proximity Read ↗

mTORC1-mediated inhibition of 4EBP1 is essential for Hedgehog (HH) signaling and can be targeted to suppress HH-driven medulloblastomaSemantic proximity Read ↗

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